|
| Status |
Public on Jan 25, 2021 |
| Title |
Identification of Natural Antisense Transcripts in Mouse Brain and Their Association with Autism Spectrum Disorder Risk Genes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed strand-specific, deep RNA sequencing to profile expression of sense and antisense reads with a focus on 100 ASD-related genes in medial prefrontal cortex (mPFC) and striatum across mouse development (P7, P14 and P56). Using de novo transcriptome assembly, we generated a comprehensive long non-coding RNA (lncRNA) transcriptome. We conducted BLAST analyses to compare the resultant transcripts with the human genome and identified transcripts with high sequence similarity and coverage.
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| |
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| Overall design |
Strand specific deep RNA sequencing of medial prefrontal cortex (mPFC) and striatum across mouse development.
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| Web link |
https://doi.org/10.3389/fnmol.2021.624881
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| |
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| Contributor(s) |
Koç B, Hall BJ, Fucile G, Giroud N, Bergauer T, Schmucki R |
| Citation(s) |
33716665 |
| |
| Submission date |
Mar 09, 2020 |
| Last update date |
Mar 16, 2021 |
| Contact name |
Roland Schmucki |
| E-mail(s) |
roland.schmucki@roche.com
|
| Organization name |
F. Hoffmann - La Roche AG
|
| Street address |
Grenzacherstrase
|
| City |
Basel |
| ZIP/Postal code |
4058 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA611551 |
| SRA |
SRP252058 |
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