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Series GSE14721 Query DataSets for GSE14721
Status Public on Feb 07, 2009
Title GENE EXPRESSION OF AN ANTI-INFLAMMATORY PENTAPEPTIDE ON CIA MURINE DEVELOPMENT
Organism Mus musculus
Experiment type Expression profiling by array
Summary Monocyte Locomotion Inhibitory Factor (MLIF), an amoebic peptide, has an anti-inflammatory role, delaying the arrival of mononuclear cells to inflammatory sites, down regulating adhesin molecules and chemokines.
We used microarrays to detail the global gene expression underlying anti-inflammatory effect of MILF in an inflammatory model. Collagen type II (CII) emulsified on complet Freund adjuvant, was injected on the tail of the base of DBA1J mice, 8 weeks older, and booster with CII emulsified in incomple Freund adjuvant three weeks later. MLIF was administrated intranasally weekly since one week before induction.

Keywords: comparison effect
 
Overall design Articular tissues of all mices were collected at the peak time of clinical severity (four weeks before booster), for RNA extraction and hybridization on Affymetrix microarrays. We induces CIA with chicken collagen type II, emulsified with Complet Adjuvant of Freund, and the controls were mice induced only with Complet Adjuvant of Freund with or without MLIF
 
Contributor(s) Velazquez JR, Godina-González S, Terán LM
Citation(s) 20582714
Submission date Feb 05, 2009
Last update date Sep 04, 2021
Contact name Juan Velazquez
E-mail(s) velazquez_juan@hotmail.com
Organization name Instituto Mexicano del Seguro Social
Street address Alameda 45
City Zacatecas
State/province Zacatecas
ZIP/Postal code 98000
Country Mexico
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (8)
GSM367773 CIA mice, biological rep1
GSM367774 CIA mice, biological rep2
GSM367775 CIA mice with MLIF, biological rep1
Relations
BioProject PRJNA112179

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE14721_RAW.tar 36.3 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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