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Series GSE14753 Query DataSets for GSE14753
Status Public on Feb 10, 2009
Title Mammary tumors from K14-cre; ApcCKO/+ mice vs control mammary glands
Organism Mus musculus
Experiment type Expression profiling by array
Summary Many components of Wnt/β-catenin signaling pathway also play critical roles in mammary tumor development. To study the role of Apc in mammary tumorigensis, we introduced conditional Apc mutations specifically into two different mammary epithelial populations using K14-Cre (progenitor) and WAP-cre (lactaing luminal) transgenic mice. Only the K14-cre mediated Apc heterozygosity developed mammary adenocarcinomas demonstrating histological and molecular heterogeneity, suggesting the progenitor cell origin of these tumors. These tumors harbored truncation mutation in a very defined region in the remaining wild-type allele of Apc that would retain some down-regulating activity of β-catenin signaling. Our results suggest that not only the epithelial origin but also a certain Apc mutations are selected to achieve a specific level of β-catenin signaling optimal for mammary tumor development.
 
Overall design We have compared 3 mammary tumors from K14-cre; ApcCKO/+ mice with 3 control mammary glands.
 
Contributor(s) Kuraguchi M, Ohene-Baah NY, Sonkin D, Bronson RT, Kucherlapati R
Citation(s) 19197353
Submission date Feb 09, 2009
Last update date Feb 11, 2019
Contact name Dmitriy Sonkin
Organization name Novartis Institutes for BioMedical Research
Street address 250 Massachusetts Avenue
City Cambridge
State/province MA
ZIP/Postal code 02139
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM368467 control mammary gland, biological replicate 1
GSM368468 control mammary gland, biological replicate 2
GSM368469 control mammary gland, biological replicate 3
Relations
BioProject PRJNA112245

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE14753_RAW.tar 22.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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