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Series GSE147549 Query DataSets for GSE147549
Status Public on Apr 19, 2024
Title Transcriptomic profiling of human pancreatic cancer-derived cell lines MiaPACA-2 depleted of TRIP12 mRNA compared to control cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary TRIP12 (Thyroid hormone Receptor Interacting Protein) is an E3 ubiquitin ligase involved in numerous cellular processes. TRIP12 controls the stability of the PTF1A transcription factor that is implicated in pancreatic cancer initiation.
To elucidate the role of TRIP12 on the expression of pancreatic cancer-derived cell lines, Trip12 mRNA expression was inhibited using a shRNA strategy. Transcriptomic profiling of shTrip12-MiaPACA-2 cell s was perfomed and compared to ShScramble control cells.
 
Overall design Two-condition experiment. MiaPACA-2 shTRIP12 vs MiaPACA-2 ShControl. Biological replicates: 4 Shcontrol replicates, 4 ShTRIP12 replicates.
 
Contributor(s) Torrisani J, Dagnon L, Martin PG, Lippi Y
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Submission date Mar 25, 2020
Last update date Apr 21, 2024
Contact name jerome torrisani
E-mail(s) jerome.torrisani@inserm.fr
Organization name inserm
Street address 2 avenue Hubert Curien
City Toulouse
ZIP/Postal code 31100
Country France
 
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (8)
GSM4433107 MiaPACA-2 cell - ShCTRL - Rep3
GSM4433108 MiaPACA-2 cell - ShTRIP12 - Rep2
GSM4433109 MiaPACA-2 cell - ShCTRL - Rep4
Relations
BioProject PRJNA615228

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE147549_RAW.tar 97.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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