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Series GSE148780 Query DataSets for GSE148780
Status Public on Dec 11, 2020
Title Memory like NK cells display stem cell like properties after Zika virus infection
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary In this study, we show that CD27+ memory like NK cells generated following Zika virus infection exhibited stem-like features viz., self-renewal pathway, differentiation into effector cells and longer telomeres, and greater therapeutic potential than CD27- and naive CD27+ NK cells when adoptively transferred to Zika virus infected mice. In addition, epigenetic landscape of CD27+ memory like NK is markedly different compared to CD27- NK cells.
 
Overall design ATACseq of naive, CD27+ (stem cell like memory) and CD27- (nonmemory) NK cells in triplicates using Illumina HiseqX.
 
Contributor(s) Kujur W, Murillo O, Adduri RS, Mulik S
Citation(s) 33370392
Submission date Apr 16, 2020
Last update date Mar 12, 2021
Contact name Sachin Mulik
E-mail(s) sachin.mulik@uthct.edu
Phone 9038772826
Organization name The University of Texas Health Science Center at Tyler
Department Pulmonary Immunology
Street address 11937 US Hwy 271
City Tyler
State/province Texas
ZIP/Postal code 75708
Country USA
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (9)
GSM4478797 Naïve NK cells_Rep1
GSM4478798 Naïve NK cells_Rep2
GSM4478799 Naïve NK cells_Rep3
Relations
BioProject PRJNA625709
SRA SRP256588

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE148780_RAW.tar 4.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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