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| Status |
Public on Mar 19, 2023 |
| Title |
Inhibition of BRD4 Rescues Cardiac phenotype in Myocyte-Specific Lamin A/C Null Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature death, which were partially rescued upon inhibition of BRD4.
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| |
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| Overall design |
RNA-seq from Cardiac myocytes from 4 control (WT) and 4 Myh6-cre:LmnaF/F vehicle treated and 4 Myh6-cre:LmnaF/F JQ1 treated
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| |
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| Contributor(s) |
Auguste G, Rouhi L, Matkovich SJ, Coarfa C, Robertson MJ, Czernuszewicz G, Gurha P, Marian AJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 22, 2020 |
| Last update date |
Mar 19, 2023 |
| Contact name |
Ali J Marian |
| E-mail(s) |
Ali.J.Marian@uth.tmc.edu
|
| Phone |
713-500-2350
|
| Organization name |
UTHSC, Houston
|
| Department |
Centre for Cardiovascular Genetics
|
| Lab |
Marian Lab
|
| Street address |
6770 Bertner Ave DAC C900a
|
| City |
Houaton |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (12)
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|
| Relations |
| BioProject |
PRJNA627374 |
| SRA |
SRP257879 |
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