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| Status |
Public on May 21, 2009 |
| Title |
CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion. Expression of CD2 distinguishes two pDC subsets with distinct phenotype and function. Both subsets secrete IFN-alpha and express Granzyme B and TRAIL. CD2high pDCs uniquely express lysozyme and can be found in tonsils and in tumors. Both subsets launch recall T cell response. However, CD2high pDCs secrete higher levels of IL12 p40, express higher levels of co-stimulatory molecule CD80 and are more efficient in triggering proliferation of naïve allogeneic T cells. Thus, human blood pDCs are composed of subsets with specific phenotype and functions.
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| |
|
| Overall design |
pDC subsets were isolated from two different donors. They were analyzed in two independent experiments.
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| Contributor(s) |
Chaussabel D |
| Citation(s) |
19454677 |
| |
| Submission date |
Mar 12, 2009 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Damien Chaussabel |
| E-mail(s) |
DChaussabel@benaroyaresearch.org
|
| Organization name |
Baylor Institute for Immunology Research
|
| Street address |
3434 Live Oak
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75204 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (4)
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| Relations |
| BioProject |
PRJNA116459 |
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