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| Status |
Public on Jun 06, 2023 |
| Title |
The transcription factor Bcl6 represses active Notch signalling in fetal thymocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We used Affymetrix microarrays to understand the genome wide differences between DMSO and Bcl6 inhibitor (79-6) anti-CD3 treated Rag1-/- E17.5 thymocytes (n=2) .
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| Overall design |
Thy1.2+ cells were sorted from anti-CD3 stimulated Rag1-/- FTOCs after 40 hours with treatment with 50uM 79-6 or DMSO alone, compared to fresh E17.5 thymi unstimulated time zero controls (n=2). RNA extracted from these sorted cells was used to perform microarrays.
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| Contributor(s) |
Solanki A, Sahni H, Crompton T |
| Citation(s) |
32907850 |
| Submission date |
Jun 16, 2020 |
| Last update date |
Jun 07, 2023 |
| Contact name |
Tessa Crompton |
| Organization name |
UCL
|
| Department |
Immunobiology
|
| Street address |
30 Guilford Street
|
| City |
London |
| ZIP/Postal code |
WC1N 1EH |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA639775 |
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