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| Status |
Public on Nov 25, 2022 |
| Title |
Isoformic PD-1 is tumorigenic in hepatocellular carcinoma through seemingly exhausted αβ T cells |
| Organisms |
Homo sapiens; synthetic construct |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Purpose: To investigate functional differences between Δ42PD-1+ and PD-1+ T cells in HCC patients
Methods: Δ42PD-1+, PD-1+ T and Δ42PD-1-PD-1- T cells were isolated by cell sorting from HCC patient’s PBMCs and performed the BD Rhapsody single-cell RNA sequencing with focus on 259 T cell-relevant transcripts
Results: Data were obtained from 3 separate T cell subsets, including 3,758 PD-1+, 3,242 Δ42PD-1+ and 4,626 Δ42PD-1-PD-1- T cells, respectively.
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| Overall design |
Comparison of T cell-relevant transcripts between Δ42PD-1+, PD-1+ T and Δ42PD-1-PD-1- T cell subsets
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| Contributor(s) |
Tan Z, Chen Z, Man K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Aug 05, 2020 |
| Last update date |
Nov 27, 2022 |
| Contact name |
Zhiwu Tan |
| E-mail(s) |
zwtan@hku.hk
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| Organization name |
University of Hong Kong
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| Department |
Microbiology
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| Lab |
AIDS Institute
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| Street address |
21 Sassoon Road, Pokfulam
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| City |
Hong Kong |
| ZIP/Postal code |
000000 |
| Country |
Hong Kong |
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| Platforms (2) |
| GPL17769 |
Illumina MiSeq (synthetic construct) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (5)
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| GSM5805236 |
HCC mRNA, sample tag and AbSeq library, Jun08 |
| GSM5805238 |
HCC mRNA, sample tag and AbSeq library, JUL14 |
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| Relations |
| BioProject |
PRJNA655458 |
| SRA |
SRP276074 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE155736_RAW.tar |
3.0 Mb |
(http)(custom) |
TAR (of CSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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