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Series GSE15624 Query DataSets for GSE15624
Status Public on Apr 10, 2009
Title Regulation of T cell gene expression by Halofuginone (HF)
Organism Mus musculus
Experiment type Expression profiling by array
Summary T cell differentiation to the Th17 effector subset requires stimulation through the T cell and co-stimulatory receptors, together with cytokine stimulation by TGFb and IL-6. The small molecule halofuginone (HF) inhibits Th17 cell development and induces a pattern of stress-regulated gene expression that mimics amino acid starvation.
We used global transcript profiling to ask how halofuginone modulates gene expression induced during T cell activaiton and Th17 differentiation

Keywords: T cell activation/ differentiation timecourse
Overall design Purified mouse CD4+ CD25- T cells were activated under Th17 polarizing cytokine conditions and treated with either halofuginone or its inactive derivative, MAZ1310, for 3- or 6-hours.
Contributor(s) Sundrud MS, Benoist C, Feuerer M
Citation(s) 19498172
Submission date Apr 10, 2009
Last update date Feb 11, 2019
Contact name CBDM Lab
Phone 617-432-7747
Organization name Harvard Medical School
Department Microbiology and Immunobiology
Street address 77 Avenue Louis Pasteur
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM391214 T cells+10nM MAZ1310 for 3 hours-biological replicate 1
GSM391215 T cells+10nM MAZ1310 for 3 hours-biological replicate 2
GSM391216 T cells+10nM MAZ1310 for 3 hours-biological replicate 3
BioProject PRJNA116595

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15624_RAW.tar 46.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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