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| Status |
Public on Oct 08, 2020 |
| Title |
Differential expression of genes associated with inflammation in KC (Kupffer cells) after partial hepatoctomy |
| Organism |
Mus musculus |
| Experiment type |
Other
|
| Summary |
The 70% resection promotes migration of Ly6C+CD11b+ monocytes/macrophages to the remnant liver accompanied by a reduction in its CD206+ macrophage content. Macrophage proliferation within the liver reaches maximum on day 3 after the surgery. Transcriptomic profiles of macrophages isolated from the regenerating livers reveal chemokine signaling signatures in combination with indications of the involvement in specific metabolic pathways rather than inflammatory effects or morphogenesis.
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| Overall design |
In the study presented here, KC samples obtained after partial hepatoctomy were used to generate expression profiles of a total of 248 unique genes associated with inflammation. For each sample, sorted cells from 5 (?) Mice were pooled.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/33765583/
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| Contributor(s) |
Nikitina M, Elchaninov A, Vishnyakova P |
| Citation(s) |
33765583 |
| |
| Submission date |
Oct 07, 2020 |
| Last update date |
Mar 26, 2021 |
| Contact name |
Polina Vishnyakova |
| E-mail(s) |
vpa2002@mail.ru
|
| Organization name |
National Medical Research Center for Obstetrics, Gynecology and Perinatology
|
| Street address |
Oparina 4
|
| City |
Moscow |
| ZIP/Postal code |
116571 |
| Country |
Russia |
| |
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| Platforms (1) |
| GPL20885 |
nCounter Mouse Inflammation panel V2 |
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| Samples (12)
|
| GSM4822446 |
Sample 1 from KC before partial hepatoctomy |
| GSM4822447 |
Sample 2 from KC before partial hepatoctomy |
| GSM4822448 |
Sample 3 from KC before partial hepatoctomy |
| GSM4822449 |
Sample 1 from KC 1 day after partial hepatoctomy |
| GSM4822450 |
Sample 2 from KC 1 day after partial hepatoctomy |
| GSM4822451 |
Sample 3 from KC 1 day after partial hepatoctomy |
| GSM4822452 |
Sample 1 from KC 3 day after partial hepatoctomy |
| GSM4822453 |
Sample 2 from KC 3 day after partial hepatoctomy |
| GSM4822454 |
Sample 1 from KC 7 day after partial hepatoctomy |
| GSM4822455 |
Sample 2 from KC 7 day after partial hepatoctomy |
| GSM4822456 |
Sample 3 from KC 7 day after partial hepatoctomy |
| GSM4822457 |
Sample 4 from KC 7 day after partial hepatoctomy |
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| This SubSeries is part of SuperSeries: |
| GSE159199 |
mRNA and microRNA profiles in KC (Kupffer cells) after partial hepatoctomy |
|
| Relations |
| BioProject |
PRJNA667933 |
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