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Series GSE160012 Query DataSets for GSE160012
Status Public on Oct 02, 2023
Title Identification of translational ncRNA biomarker candidates for nano-polystyrene induced brain injury using next-generation sequencing
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary The exposure to nano-plastics affects mammalian neurotoxic hazard characterization remains to be determined. Our aim was to investigate the neurotoxicity of nano-plastics in rodents. Animals were randomly divided into two groups: a control group and 50 mg/kg body weight PS NPs treatment groups. Before treatment, animals were fasted overnight. PS NPs were suspended into waters, vigorously stirred. The PS NPs via oral gavage once per day and for 6 months. The mice were treated with water in control group. We found that exposure to PS NPs caused cognitive decline. PS NPs exposure influenced the prefrontal cortex cells with more pathological alteration with increasing dosage. High-throughput RNA sequencing was conducted to explore miRNA expression in prefrontal cortex. Sixty-seven differentially expressed circRNAs were detected, including 25 upregulated and 42 downregulated circRNAs. We also explored 987 differentially expressed mRNAs, including 477 upregulated and 510 downregulated mRNAs.
Overall design Mice exposure PS NPs for half year and identified of translational circRNA, LncRNA as well as mRNA
Contributor(s) Chen C, Rong Z
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Submission date Oct 24, 2020
Last update date Oct 02, 2023
Contact name chu chen
Organization name Hebei medical university
Department Department of Toxicology
Street address 361 Zhongshan East Road
City Shijiazhuang
State/province Hebei
ZIP/Postal code 050017
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM4852486 CON_1
GSM4852487 CON_2
GSM4852488 CON_3
BioProject PRJNA671603
SRA SRP288439

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Supplementary file Size Download File type/resource
GSE160012_circRNA_expression_fpkm.txt.gz 3.1 Mb (ftp)(http) TXT
GSE160012_linear_isoforms_expression_fpkm.txt.gz 13.5 Mb (ftp)(http) TXT
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