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Series GSE16049 Query DataSets for GSE16049
Status Public on May 12, 2009
Title Expression in myocardial tissues of Great Dane dogs with cardiomyopathy
Organism Canis lupus familiaris
Experiment type Expression profiling by array
Summary Oligonucleotide microarray analysis of left ventricular tissues from 3 Great dane dogs with dilated cardiomyopathy and 3 control dogs was performed. Three hundred and twenty three differentially expressed transcripts were detected. The transcript demonstrating the highest degree of upregulation was FKBP12.6 (calstabin2) and the transcript with the greatest amount of down regulation was triadin. Both of these transcripts are critical to proper functioning of the cardiac ryanodine receptor. Abnormalities of both calstabin2 and triadin have been reported in humans with heart disease. Further investigation into the role of calstabin2 and triadin in canine cardiomyopathy is warranted, and the canine disease may serve as a model of human disease.

Keywords: control vs diseased
 
Overall design 3 controls and 3 affected
 
Contributor(s) Oyama MA, Chittur SV
Citation(s) 19674278
Submission date May 11, 2009
Last update date Mar 21, 2012
Contact name Sridar V Chittur
E-mail(s) schittur@albany.edu
Phone 518-591-7215
Organization name SUNY-University at Albany
Department Center for Functional Genomics
Lab Microarray Core
Street address One Discovery Drive, CRC 342G
City Rensselaer
State/province NY
ZIP/Postal code 12144
Country USA
 
Platforms (1)
GPL3738 [Canine_2] Affymetrix Canine Genome 2.0 Array
Samples (6)
GSM401531 control, biological rep1
GSM401532 control, biological rep2
GSM401533 control, biological rep3
Relations
BioProject PRJNA114991

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16049_RAW.tar 23.8 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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