NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE160573 Query DataSets for GSE160573
Status Public on Oct 01, 2023
Title Bromodomain protein inhibition protects β-cells from cytokine-induced death and dysfunction via antogonism of NF-κB pathway
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary We report that BET inhibitor (I-BET762) protect against cytokine induced pancreatic beta-cell apoptosis and did RNA-Seq to determine global transcriptome changes with the drug.
 
Overall design Rat insulinoma cell line (INS1) were treated with vehicle control (VC), I-BET762 (IB), ctyokine with vehicle control (CCVC) and cytokines with I-BET762 (CCIB) for 72h with cytokines added in last 24h.
contributor: Novogene
 
Contributor(s) Negi V, Yechoor V
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Oct 31, 2020
Last update date Oct 01, 2023
Contact name Vijay Yechoor
E-mail(s) yechoorv@pitt.edu
Organization name University of Pittsburgh
Department Vascular Medicine Institute
Street address 200 Lothrop street,
City Pittsburgh
State/province PA
ZIP/Postal code 15261
Country USA
 
Platforms (1)
GPL25947 Illumina NovaSeq 6000 (Rattus norvegicus)
Samples (12)
GSM4875534 VC_1
GSM4875535 VC_2
GSM4875536 VC_4
Relations
BioProject PRJNA673623
SRA SRP290580

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE160573_HEATMAP_ANNOTATION_1_.xlsx 6.5 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap