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Series GSE161341 Query DataSets for GSE161341
Status Public on Feb 04, 2021
Title The Breast Cancer Susceptibility Gene TOX3 Promotes Estrogen Synthesis: An RNA-sequencing and Network Study
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We aimed to explore the effect of the breast cancer susceptibility gene TOX3 on estrogen synthesis from the perspective of estrogen production, in an attempt to link abnormalities in hormone production with the development of breast cancer. After overexpression of TOX3, several crucial key genes and pathways that contribute to estrogen production were upregulated. Forced expression of TOX3 also promotes proliferation and inhibits apoptosis of granulosa cells. These findings discuss the possible impact of susceptibility genes and steroid hormones on breast cancer from the perspective of extra-mammary tissues such as those in the ovary, thus providing new insights for early prevention and treatment of breast cancer.
Overall design KGN mRNA profiles of TOX3 overexpression and control group
Contributor(s) Man Y
Citation(s) 33716953
Submission date Nov 12, 2020
Last update date Mar 16, 2021
Contact name Yuanyuan Man
Phone +8617865139105
Organization name Shandong University
Department Center for Reproductive Medicine
Street address No.157, Jingliuweiwu Road
City Jinan
State/province Shandong
ZIP/Postal code 250100
Country China
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (4)
GSM4905063 CON_1
GSM4905064 CON_2
GSM4905065 TOX3_1
BioProject PRJNA677925
SRA SRP292320

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Supplementary file Size Download File type/resource
GSE161341_RPKM.xlsx 2.4 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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