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Series GSE16138 Query DataSets for GSE16138
Status Public on Dec 31, 2009
Title Transcriptome analysis of mesothelioma induced by intraperitoneal injections of ferric saccharate in rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Iron plays an important role in oxidative tissue damage and subsequent carcinogenesis. Iron deposition in the peritoneum causes neoplastic changes. Here we used gene expression microarrays to find common genetic alterations in a rat model by repeated intraperitoneal injections of ferric saccharate. Gene expression microarray revealed the expression of uromodulin (Umod) is increased in mesothelioma approximately 250-fold.
Overall design Carcinogenesis protocol was performed using specific pathogen-free male and female F1 hybrid rats between Fischer344 and Brown-Norway strains. A total of 12 microarrays (Whole Rat Genome Oligo Microarrary) were used for the screening purpose;
The scraped pleural mesothelial cells of 8 week male rat untreated or peri-testicular tissue as control; Induced mesothelioma of epithelioid and sarcomatoid types.
Contributor(s) Toyokuni S, Hu Q, Akatsuka S
Citation(s) 20065947
Submission date May 17, 2009
Last update date Sep 13, 2014
Contact name Shinya Toyokuni
Organization name Nagoya University
Department Pathology
Street address 65 Tsuruma-Cho, Showa-Ku
City Nagoya
State/province Aichi
ZIP/Postal code 466-8550
Country Japan
Platforms (1)
GPL7294 Agilent-014879 Whole Rat Genome Microarray 4x44K G4131F (Probe Name version)
Samples (12)
GSM401388 Control_methoserial_1
GSM402895 Control_methoserial_2
GSM402897 Control_peri-testicular_1
BioProject PRJNA115039

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16138_RAW.tar 93.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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