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Series GSE162848 Query DataSets for GSE162848
Status Public on Oct 14, 2021
Title Revealing pathways associated with feed efficiency and meat quality traits in slow-growing chicken
Organism Gallus gallus
Experiment type Expression profiling by array
Summary Improvement of feed efficiency would increase profitability of the poultry industries by decreasing the amount of feed required for production. Korat (KR) chicken is a new alternative meat-type chicken breed which its meat is recognized for its high protein, low fat and low purine content, whereas its low feed efficiency leads to high cost of production. Deeper understanding on how feed efficiency influences meat quality is poorly elucidated. To fulfill deeper understand molecular key that point the variation in feed efficiency and meat quality, the aim of this study was to investigate molecular pathways and genes involved in feed efficiency and meat quality in thigh of slow-growing KR chicken. A total of 75 males KR chicken were reared in individual cage until 10 weeks of age. Individual feed intake and body weight were collected weekly to calculate Feed Conversion Ratio (FCR) and Residual Feed Intake (RFI). Meat quality parameters were measured in thigh muscles such as ultimate pH (pHu), water-holding capacity (WHC), drip loss (DL), nucleotides content and several biomolecules (amide, …). Base on extreme values of FCR at 10 weeks of ages, 12 birds from the high FCR group (HFCR) and 9 birds from the low FCR group (LFCR) were selected for investigating their transcriptome using an 8×60K Agilent chicken microarray. In addition, a weighted gene coexpression network analysis was performed to detect the relationship between modules of co-expressed genes and feed efficiency, meat quality in thigh muscle. The result in this study indicated that selection on feed efficiency (FCR, RFI) would affect flavor precursor, lipid and protein content in thigh muscle. Based on WGCNA and functional enrichment analysis, results suggested that the key molecular pathways relate to FCR, RFI and meat quality (WHC, DL, IMP, AMP and inosine) in thigh muscle were the pathways of regulation of biological process, biological regulation and regulation of metabolic. Moreover, we revealed four genes there are assembly competence domain (ACD) gene, baculoviral IAP repeat containing 5 (BIRC5) gene, cytochrome c oxidase assembly factor 3 (COA3) gene and myosin light chain 9 (MYL9) gene that might be biomarker gene in feed efficiency and meat quality in thigh muscle. The hypothesis of the current study was alteration feed efficiency in slow-growing chicken will impact meat quality especially in term of texture and flavor.
Overall design Gene expression was measured in thigh muscles from two groups: high FCR (HFCR, n=12) and low FCR (LFCR, n=9), at 10 weeks of age.
Contributor(s) Poompramun C, Hennequet-Antier C, Thumanu K, Molee W, Molee A, Le Bihan-Duval E, Juanchich A
Citation(s) 34679997
Submission date Dec 08, 2020
Last update date Oct 27, 2021
Contact name Chotima Poompramun
Phone 0636545542
Organization name Suranaree University of Technoogy
Department School of Animal Technology and Innovation
Lab animal bredding
Street address School of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology
City Nakhonratchasima
State/province Nakhon Ratchasima
ZIP/Postal code 30000
Country Thailand
Platforms (1)
GPL20588 Agilent-037360 gallus_exp_microarray_SLagarrigue_8x60k_V1
Samples (24)
GSM4962851 Muscle_LFCR_01
GSM4962852 Muscle_HFCR_01
GSM4962853 Muscle_LFCR_02
BioProject PRJNA683588

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Supplementary file Size Download File type/resource
GSE162848_RAW.tar 271.0 Mb (http)(custom) TAR (of TXT)
GSE162848_processed_data.txt.gz 5.7 Mb (ftp)(http) TXT
Processed data are available on Series record

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