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| Status |
Public on Jun 02, 2009 |
| Title |
Gene expression profiling of muscles from transgenic humanSODG93A mice at symptomatic stage |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The transgenic mice expressing the human mutated form (G93A) of the SOD1 gene represent a valuable model of Amyotrophic Lateral Sclerosis (ALS). SOD1 is one of the main causative genes of familial ALS which accounts for 10% of cases. These transgenic animals develop a motorneuronal pathology that recapitulates well the neuropatological features occuring in ALS patients, and the progression of the disease can be monitored by a series of motor tests. Gastrocnemius is first and most affected muscle in the disease, while triceps is relatively spared.
Gene expression data of degenerating motor neurons at different disease stages are already available, while gene expression data on the muscle tissue are missing. Our aim is to define the role of muscle in motor neuron degeneration in ALS.
Keywords: Single stage analysis (early symptomatic stage, 14 weeks-old mice)
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| Overall design |
We considered two sets of muscle at symptomatic stage (14 weeks): gastrocnemius and triceps from 4 transgenic SOD1G93A and 4 non-transgenic mice (NTg). Gastrocnemius from 4 nerve-crushed mice were also considered as controls for the denervation process
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| Contributor(s) |
Ratti A, Calza S, Volta M |
| Citation missing |
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| Submission date |
Jun 01, 2009 |
| Last update date |
May 04, 2018 |
| Contact name |
Antonia Ratti |
| E-mail(s) |
antonia.ratti@unimi.it
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| Organization name |
IRCCS Istituto Auxologico Italiano, University of Milan
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| Department |
Dept. Neurological Sciences
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| Lab |
Lab. Neuroscience
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| Street address |
Via Zucchi, 18
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| City |
Cusano Milanino |
| State/province |
Milan |
| ZIP/Postal code |
20095 |
| Country |
Italy |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (20)
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| GSM410733 |
NTg-triceps-14w, biol rep1 |
| GSM410734 |
NTg-gastro-14w, biol rep2 |
| GSM410735 |
NTg-triceps-14w, biol rep2 |
| GSM410736 |
SOD1G93A gastro-14w, biol rep2 |
| GSM410737 |
SOD1G93A triceps-14w, biol rep2 |
| GSM410738 |
NTg-gastro-14w, biol rep3 |
| GSM410739 |
NTg-triceps-14w, biol rep3 |
| GSM410740 |
SOD1G93A gastro-14w, biol rep3 |
| GSM410741 |
SOD1G93A triceps-14w, biol rep3 |
| GSM410742 |
SOD1G93A gastro-14w, biol rep4 |
| GSM410743 |
SOD1G93A triceps-14w, biol rep4 |
| GSM410744 |
NTg-gastro-14w, biol rep4 |
| GSM410745 |
NTg-triceps-14w, biol rep4 |
| GSM410746 |
Crushed-gastro-14w, biol rep1 |
| GSM410747 |
Crushed-gastro-14w, biol rep2 |
| GSM410748 |
Crushed-gastro-14w, biol rep3 |
| GSM410749 |
Crushed-gastro-14w, biol rep4 |
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| This SubSeries is part of SuperSeries: |
| GSE16362 |
ALS mice muscle gene expression data |
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| Relations |
| BioProject |
PRJNA122851 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE16361_RAW.tar |
49.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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