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Series GSE164357 Query DataSets for GSE164357
Status Public on Feb 04, 2021
Title Interleukin-1α mediates innate and acquired resistance to immunotherapy in melanoma
Organism Mus musculus
Experiment type Expression profiling by array
Summary In a syngeneic mouse model of melanoma, we found that tumor size was inversely correlated with response to immunotherapy. Large tumors had higher levels of IL-1α, Th2 cytokines, granulocytic myeloid-derived suppressor cells (GMDSCs), and regulatory T cells but lower levels of IL-12, Th1 cytokines, and activated CD4+ and CD8+ T cells. Blocking IL-1 signaling decreased GMDSCs and their associated PD-L1 expression in the tumor microenvironment, and enhanced tumor-specific immunity.
 
Overall design C57BL/6 mice were inoculated with the syngeneic B16 melanoma cell line, and after 8 days developed tumors that were either small (10-20 mm2) or large (70-80 mm2). Gene expression analysis was used to compared small vs. large tumors.
 
Contributor(s) Singh S, Wang Z, Davis RE, Overwijk WW, Singh M
Citation(s) 33722878
Submission date Jan 06, 2021
Last update date Apr 20, 2021
Contact name Richard Eric Davis
E-mail(s) redavis1@mdanderson.org
Phone 4437456831
Organization name MD Anderson Cancer Center
Street address 7455 Fannin Street
City Houston
State/province TX
ZIP/Postal code 77054
Country USA
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (6)
GSM5008099 L1 Large tumor
GSM5008100 L2 Large tumor
GSM5008101 L3 Large tumor
Relations
BioProject PRJNA690100

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE164357_RAW.tar 15.8 Mb (http)(custom) TAR
GSE164357_non-normalized.txt.gz 1.8 Mb (ftp)(http) TXT
Processed data included within Sample table

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