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Series GSE165507 Query DataSets for GSE165507
Status Public on Jun 30, 2023
Title single cell RNA Sequencing of hippocampi of mice subjected or not to the learned helplessness paradigm
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The goal of the study was to identify the hippocampal microenvironment asscoaited with stress, in particular stress-induced learned helplessness. By comparing chronic and acute induction of learned helplessness, we identified cell populations and genes associated with resilience.
Overall design Mice were subjected or not to the learned helplessness paradigms (either acute: mice received footshocks and were tested the next day, or chronic: mice received the acute paradigm and are retested for 3 weeks, weekly), and hippocampal CD45+ live dead - cells were sorted, and 10X Genomics single cell RNA Sequencing was performed.
Contributor(s) Beurel E
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NIH grant(s)
Grant ID Grant title Affiliation Name
R01 MH110415 The microbiota, a possible link between Th17 cells and depression University of Miami School of Medicine Eleonore Beurel
R01 MH104656 Th17 cells as a new therapeutic target for depression University of Miami School of Medicine Eleonore Beurel
Submission date Jan 25, 2021
Last update date Jun 30, 2023
Contact name Eleonore Beurel
Phone 2059832516
Organization name University of Miami, Miller School of Medicine
Department Psychiatry
Street address 1011 NW 15th Street Gautier room 415
City Miami
State/province FL
ZIP/Postal code 33136
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (6)
GSM5034809 NS (non shocked)
GSM5034810 ND24 (non-learned helpless in the acute paradigm)
GSM5034811 Dep24 (learned helpless in the acute paradigm)
BioProject PRJNA694767
SRA SRP303241

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE165507_RAW.tar 46.9 Mb (http)(custom) TAR (of TSV)
GSE165507_SamplesMerged-CellMetadata.tsv.gz 97.6 Kb (ftp)(http) TSV
GSE165507_SamplesMerged-CountMatrix-normalized.tsv.gz 48.4 Mb (ftp)(http) TSV
GSE165507_SamplesMerged-CountMatrix-raw.tsv.gz 6.5 Mb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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