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GEO help: Mouse over screen elements for information. |
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Status |
Public on Feb 04, 2021 |
Title |
CD62L expression level determines the cell fate of myeloid progenitors in mice and humans |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Through gene expression analysis of CMPs and GMPs at single cell levels, we identified CD62L as a marker to reveal the heterogeneity of CMPs and GMPs. We confirmed that the CD62L-low CMPs represent ‘bona fide’ CMPs, whereas CD62L-high CMPs are mostly restricted to GMP potentials both in mice and humans. In addition, we identified CD62L-neg GMPs as the most immature subsets in GMPs and Ly6c+CD62L-low and Ly6c+CD62L-high GMPs are skewed to neutrophil and monocyte differentiation, respectively. We performed gene expression profiling of CD62L-low CMPs, CD62L-high CMPs, CD62L-neg GMPs, CD62L-low GMPs, CD62L-high GMPs, bulk CMPs, and bulk GMPs.
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Overall design |
Gene expression profiling of CD62L-low CMPs, CD62L-high CMPs, CD62L-neg GMPs, CD62L-low GMPs, CD62L-high GMPs, bulk CMPs, and bulk GMPs
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Contributor(s) |
Ito Y |
Citation(s) |
34798065 |
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Submission date |
Feb 03, 2021 |
Last update date |
Apr 17, 2023 |
Contact name |
Yusuke Ito |
E-mail(s) |
yuusuitou-tky@umin.ac.jp
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Phone |
+81333531211
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Organization name |
Keio University
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Department |
Division of Tumor Immunology
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Street address |
35 Shinanomachi
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City |
Shinjuku-ku |
State/province |
Tokyo |
ZIP/Postal code |
1608582 |
Country |
Japan |
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Platforms (1) |
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Samples (21)
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Relations |
BioProject |
PRJNA699169 |
SRA |
SRP304498 |
Supplementary file |
Size |
Download |
File type/resource |
GSE166065_read-count.txt.gz |
730.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
Raw data are available in SRA |
Processed data are available on Series record |
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