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Series GSE171936 Query DataSets for GSE171936
Status Public on Apr 14, 2021
Title Genome-wide RNA-sequencing differences in nucleus accumbens of smokers vs. nonsmokers
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Cigarette smoking remains the leading cause of preventable death worldwide. Cigarette smoking behaviors (e.g., initiation, nicotine dependence, cessation) are heritable, and many genetic risk loci have been identified. However, the neurobiological mechanisms underlying the genetic risk loci along the trajectory of smoking are largely unknown. RNA-sequencing (RNA-seq) differences between smokers and nonsmokers can provide insight into mechanisms that predispose to smoking behaviors and consequences of the smoking exposure itself. Here, we provide RNA-seq data generated in nucleus accumbens, an addiction-relevant brain tissue, from 223 deceased individuals: 50 current cigarette smokers, 171 nonsmokers, and 2 individuals with undetermined smoking status. DNA methylation data on the Illumina HumanMethylationEPIC array are also available on most of these individuals and made available (GEO accession number GSE147040).
 
Overall design RNA-seq data were measured in postmortem nucleus accumbens bulk tissue. The dataset includes 223 deceased individuals, including 50 current cigarette smokers, 171 nonsmokers, and 2 individuals with undetermined smoking status.
 
Contributor(s) Hancock D
Citation(s) 32731254
Submission date Apr 12, 2021
Last update date Jul 14, 2021
Contact name Dana Hancock
E-mail(s) dhancock@rti.org
Phone 9195416701
Organization name RTI International
Street address 3040 E Cornwallis Rd
City Research Triangle Park
State/province NC
ZIP/Postal code 27709
Country USA
 
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (223)
GSM5237605 201516280022_R03C01_Nonsmoker
GSM5237606 201516280017_R02C01_Nonsmoker
GSM5237607 201516250010_R03C01_Nonsmoker
Relations
BioProject PRJNA721610
SRA SRP314642

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Supplementary file Size Download File type/resource
GSE171936_nac_rnaseq_salmon_dge_gene_data_counts_filters.csv.gz 15.5 Mb (ftp)(http) CSV
GSE171936_nac_rnaseq_salmon_dge_gene_data_length_filters.csv.gz 43.4 Mb (ftp)(http) CSV
GSE171936_nac_rnaseq_salmon_dge_gene_data_tpm_filters.csv.gz 26.9 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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