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| Status |
Public on Sep 30, 2009 |
| Title |
A Dysregulated Proinflammatory Status in Preterm School-aged Children with PVL-induced Spastic Cerebral Palsy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Injury occurring during critical periods of development may have long-term effects on inflammatory responses. Periventricular leukomalacia (PVL) is the most common cause of cerebral palsy (CP) in preterm infant. Activated leukocytes are the main source of inflammatory cytokines that give rise to white matter damage and CP in preterm infant. Here, we tested the hypothesis that inflammation profiles as pathogenic mediators for the occurrence of PVL in the neonatal period may persist in preterm children with CP at school age.
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| Overall design |
Five preterm children with PVL-induced CP and gestational age-matched five preterm children with normal neurodevelopment were recruited from follow up clinics. Proinflammatory gene expression in the PBMCs from preterm children were determined by Superarray PCR study.
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| Contributor(s) |
Lin C, Chang Y, Wnag S, Lee T, Lin C, Huang C |
| Citation(s) |
20695013 |
| |
| Submission date |
Jul 29, 2009 |
| Last update date |
Sep 18, 2012 |
| Contact name |
Chang-yi Lin |
| E-mail(s) |
s5893153@mail.ncku.edu.tw
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| Organization name |
National Cheng Kung University
|
| Department |
institute of basic medical science
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| Street address |
No.1, University Road
|
| City |
Tainan |
| ZIP/Postal code |
701 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL8930 |
Human Tumor Necrosis Factor (TNF) Ligand and Receptor PCR Array cat. #PAHS-063 |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA118827 |
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