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Series GSE174283 Query DataSets for GSE174283
Status Public on Mar 13, 2023
Title Dissecting the interface between ARID1A and mRNA translation in bladder cancer (Polysome)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Chromatin remodeling and protein synthesis are tightly regulated processes that impact gene expression and cellular phenotypes. However, it is unknown if these two regulatory mechanisms are linked or exert independent effects in normal epithelial physiology and disease states. We have uncovered a new functional relationship between the chromatin remodeler ARID1A and mRNA translation elongation that is involved in cancer initiation and progression.
Overall design Polysome to Subpolysome Profiling and RNASeq of samples
Contributor(s) Jana S, Arora S, Hsieh A
Citation(s) 37084735
Submission date May 11, 2021
Last update date Jun 20, 2023
Contact name Sonali Arora
Organization name FHCRC
Street address 1100 Fairview Ave N,
City Seattle
State/province WA
ZIP/Postal code 98109
Country USA
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (22)
GSM5290983 WT REPLICATE 1 (total mRNA)
GSM5290984 WT REPLICATE 1 (Subpolysome fraction)
GSM5290985 KO REPLICATE 1 (total mRNA)
This SubSeries is part of SuperSeries:
GSE201222 Dissecting the interface between ARID1A and mRNA translation in bladder cancer
BioProject PRJNA729094
SRA SRP319569

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE174283_RAW.tar 2.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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