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Series GSE175588 Query DataSets for GSE175588
Status Public on Jan 14, 2022
Title Sustained down-regulation of alphaSmooth muscle actin expression in aortas induced by angiotensin II: a new model of vascular memory to hypertension
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We developped a new model of vascular injury memory in response to AngII stimulation in mice. We used RNAseq (aortas) to try to understand observed sustained phentoype and identify Acta2 (aSMA) as key in observed phenomenon.
 
Overall design 11-week male C57B6 mice were implanted with osmotic minipumps delivering of 2.8mg/kg/day of AngII for 2 weeks. Mice were sacrificed at the end of the treatment (AngII); and after 2 and 3 weeks of AngII (AngII+2W; Ang+3W, respectively). Age matched littermate served as control. Aortic mRNA profile was compared: CTRL vs AngII; CTRL vs AngII+2W; and CTRL vs AngII+3W
 
Contributor(s) Pothen L, Balligand JL, Bearzatto B, Ambroise J
Citation(s) 35360022
Submission date May 26, 2021
Last update date Apr 07, 2022
Contact name Jérôme Ambroise
E-mail(s) jambroise83@gmail.com
Organization name Université catholique de Louvain
Department Institut de Recherche Expérimentale et Clinique
Street address Avenue Hippocrate 54
City Woluwé
ZIP/Postal code 1200
Country Belgium
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (8)
GSM5342186 Angio 2w-rep1 [AorteA]
GSM5342187 Angio 2w-rep2 [AorteB]
GSM5342188 Angio 2w+2W -Rep1 [AorteC]
Relations
BioProject PRJNA732945
SRA SRP321500

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Supplementary file Size Download File type/resource
GSE175588_RNA.seq.counts.csv.gz 551.5 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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