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| Status |
Public on Oct 05, 2010 |
| Title |
Widespread over-expression of the X chromosome in sterile F1 hybrid mice |
| Platform organism |
Mus musculus |
| Sample organisms |
Mus musculus; Mus musculus domesticus; Mus musculus musculus x M. m. domesticus |
| Experiment type |
Expression profiling by array
|
| Summary |
We used a reciprocal cross of Mus musculus and M. domesticus in which F1 males are sterile in one direction and fertile in the other direction, in order to associate expression differences with sterility.
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| Overall design |
Four different crosses were performed. A cross between two strains within each mouse species (M. musculus, PWK/PhJ and CZECHII/EiJ; M. domesticus, LEWES/EiJ and WSB/EiJ). And two reciprocal crosses between a domesticus (LEWES/EiJ) and a musculus (PWK/PhJ) strain. The cross between a musculus female and a domesticus male produces sterile male offspring - whereas all other crosses produced fertile male offspring. Testis tissue from three male mice (60 days old) from all four crosses were analysed on the Affymetrix MG 430.2. Array.
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| Contributor(s) |
Good JM, Giger T, Dean MD, Nachman MW |
| Citation(s) |
20941395 |
| |
| Submission date |
Aug 17, 2009 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Thomas Giger |
| E-mail(s) |
giger@eva.mpg.de
|
| Organization name |
Max-Planck-Institute of Evolutionary Anthropology
|
| Department |
Evolutionary Genetics
|
| Street address |
Deutscher Platz 6
|
| City |
Leipzig |
| ZIP/Postal code |
04106 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL6886 |
Mouse Genome 430 2.0 Array [Mouse4302_Mm_ENSG (v11.0.1) CDF] |
|
| Samples (12)
|
| GSM441176 |
testis fertile M. musculus rep 1 |
| GSM441177 |
testis fertile M. musculus rep 2 |
| GSM441178 |
testis fertile M. musculus rep 3 |
| GSM441179 |
testis fertile F1 domesticus/musculus rep1 |
| GSM441180 |
testis fertile F1 domesticus/musculus rep2 |
| GSM441181 |
testis fertile F1 domesticus/musculus rep3 |
| GSM441182 |
testis sterile F1 musculus/domesticus rep1 |
| GSM441183 |
testis sterile F1 musculus/domesticus rep2 |
| GSM441184 |
testis sterile F1 musculus/domesticus rep3 |
|
| Relations |
| BioProject |
PRJNA118417 |
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