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Series GSE178515 Query DataSets for GSE178515
Status Public on Jun 12, 2024
Title Transcriptomic responses in the host during mosquito-transmitted and blood passaged Plasmodium chabaudi infections.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Plasmoidium chabuadi AS infections initiated by mosquito transmitted infections give rise to an attenuated blood-stage infection when compared to serially blood passaged parasites. Furthermore, Plasmoidium chabuadi CB infections have an increased virulence as compared with Plasmoidium chabuadi AS. We compared the immune response in the spleens induced by these two types of parasites and two types of infection routes in order to determine what may cause this attenuation. Spleens were taken at several timepoints during the blood-stage infection and RNA-seq analysis was performed.
 
Overall design 6 Time points - (Days post blood cycle infection 3,6,9,12,30, 60) 2 infection conditions (MT and SBP) and two parasite strains (P.chaubadi AS and P.chabaudi CB). Each group used age/sex matched C57BL/6 mice, with at least 3 replicates in infection groups. Controls/Naïve mouse with no infection were age/sex matched.
 
Contributor(s) Lin J, Alder C, Hosking C, Manni S
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Submission date Jun 20, 2021
Last update date Jun 12, 2024
Contact name Jean Langhorne
Organization name Francis Crick Institute
Street address 1 Midland Road
City London
ZIP/Postal code N1 1ST
Country United Kingdom
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (87)
GSM5393160 Naive Day 3 Rep 1
GSM5393161 Naive Day 3 Rep 2
GSM5393162 Naïve Day 6 Rep 1
Relations
BioProject PRJNA739466
SRA SRP324748

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Supplementary file Size Download File type/resource
GSE178515_CB_Counts_full.tsv.gz 3.6 Mb (ftp)(http) TSV
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Raw data are available in SRA
Processed data are available on Series record

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