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| Status |
Public on Dec 15, 2021 |
| Title |
Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Chronic rhinosinusitis with nasal polyps is a hallmaerk disease in the field of upper airway immunity and chronic inflammation. Diverse inflammatory patterns between nasal polyps have been described in patients that hail from disparate racial and geographic backgrounds. However, it remains unclear whether these immunologic differences in nasal polyps between racial groups are driven by unique molecular mechanisms. We interrogated the gene expression profiles of nasal polyp tissues from Western (United States) and East Asian (Japan) descent, compared to ethmoid sinus tissue controls.
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| |
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| Overall design |
Examination of the molecular differences between Caucasian (n=8), Asian CRSwNP (n=9), and contol (n=7) using whole-transcriptome RNA sequencing.
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| |
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| Contributor(s) |
Nakayama T, Lee I, Ziang S, Nayak JV |
| Citation(s) |
34863854 |
| |
| Submission date |
Jul 01, 2021 |
| Last update date |
Dec 15, 2021 |
| Contact name |
Tsuguhisa Nakayama |
| Organization name |
Stanford University
|
| Department |
Department of Otolaryngology-Head and Neck Surgery
|
| Street address |
801 Welch Road
|
| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (24)
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| This SubSeries is part of SuperSeries: |
| GSE179269 |
Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations |
|
| Relations |
| BioProject |
PRJNA743028 |
| SRA |
SRP326492 |
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