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Series GSE179884 Query DataSets for GSE179884
Status Public on Dec 01, 2023
Title Chromomal translocations induced by CRISPR-Cas9 persist in expanded T cells
Organism Mus musculus
Experiment type Other
Summary Chromosomal translocations cause various lymphoid cancers and are prevalent in CRISPR-Cas9-meidated gene editing. However, the fate of gene editing-induced translocations remains elusive in vivo. Here, we found that translocations in engineered T cells experience clonal expansion after transferring into recipients for three weeks and remains comparable level with edited T cell before transfer, arguing against the notion that translocations would be gradually lost during cell proliferation due to growth retardation.
Overall design Examination of the fate of chromosomal translocation induced by gene editing in T cells
Contributor(s) Liu Y, Wu J, Hu J
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Submission date Jul 11, 2021
Last update date Dec 01, 2023
Contact name Yang Liu
Organization name School of life sciences, Peking University
Lab Jiazhi Hu lab
Street address Yiheyuan Road, No. 5
City Beijing
ZIP/Postal code 100871
Country China
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (6)
GSM5436498 Naïve_T_primer_control
GSM5436499 Activated_T
GSM5436500 Effector_T_1
BioProject PRJNA745461
SRA SRP327854

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE179884_RAW.tar 23.1 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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