|
| Status |
Public on Dec 03, 2022 |
| Title |
Mettl3 regulates late-stage retinogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To study the function of Mettl3 during retinal development, we used Six3-Cre and Mettl3floxed mice to conditionally knock out Mettl3 from retinal progenitor cells. The mutant mice show defects in late-stage retinogenesis and structural and physiological homeostasis of the retina.
|
| |
|
| Overall design |
Retinas of postnatal day 7 Six3-Cre+; Mettl3floxed/floxed mice (4 samples), as well as retinas of their littermate control mice (4 samples), were collected into TRIZol, and processed for RNA-seq.
|
| |
|
| Contributor(s) |
Chen S |
| Citation(s) |
36459087 |
| |
| Submission date |
Jul 25, 2021 |
| Last update date |
Dec 15, 2022 |
| Contact name |
SHUYI CHEN |
| E-mail(s) |
chenshy23@mail.sysu.edu.cn
|
| Organization name |
Zhongshan Ophthalmic Center, SYSU
|
| Department |
State Key Laboratory of Ophthalmology
|
| Street address |
54 S. Xianlie Rd
|
| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510060 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (8)
|
|
| This SubSeries is part of SuperSeries: |
| GSE180815 |
Mettl3 regulates late-stage retinogenesis and mouse retina m6A epitranscriptome |
|
| Relations |
| BioProject |
PRJNA749618 |
| SRA |
SRP329821 |
Less...
More...