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Series GSE18131 Query DataSets for GSE18131
Status Public on Jan 01, 2010
Title Expression from C. elegans L4 animals
Organism Caenorhabditis elegans
Experiment type Expression profiling by array
Summary Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. Knockouts of the O-GlcNAc cycling enzymes in C. elegans are viable and fertile, allowing a global analysis of the impact of GlcNAcylation.
Whole genome transcriptional profiling of the O-GlcNAc cycling mutants confirmed dramatic deregulation of genes in these key pathways. As predicted, the O-GlcNAc cycling mutants show phenotypically altered lifespan and susceptibility to UV stress.
Overall design Similarly aged L4 animals (20) staged by degree of vulval development were hand picked. Wild type and mutant animals were collected and total RNA isolated for gene expression analysis
Contributor(s) Krause M, Hanover J
Citation(s) 20368426, 30250452
Submission date Sep 16, 2009
Last update date Jun 11, 2019
Contact name Michael Krause
Phone (301) 402-4633
Organization name NIH
Department LMB/NIDDK
Lab Krause
Street address 5 Center Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL200 [Celegans] Affymetrix C. elegans Genome Array
Samples (9)
GSM453407 WT Fed L4, biological rep1
GSM453408 WT Fed L4, biological rep2
GSM453409 WT Fed L4, biological rep3
This SubSeries is part of SuperSeries:
GSE18132 Dynamic O-GlcNAc cycling at promoters of C. elegans genes regulating Longevity, Stress, and Immunity
BioProject PRJNA123477

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE18131_RAW.tar 64.8 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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