DNA methylation profiles were generated for cases in the SIOP ependymoma I study. Samples were analysed using the Illumina 450k BeadChip and processed using the Heidelberg classifier (v11.2b). The aim of the biological studies aspect of the trial was to perform a retrospective analysis of the methylation profiles of the participants in the trial.
Overall design
35 samples were analysed and found to be consistent with ependymoma (74 participants in the study but the remainder did not have tissue available for analysis).