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| Status |
Public on May 31, 2022 |
| Title |
Transcriptome analysis of HLA-DR(+) HSPCs and HLA-DR(-) HSPCs in aplastic anemia patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by SAGE
|
| Summary |
HLA-DR-lacking HSPCs [HLA-DR(-) HSPCs] were detected in aplastic anemia (AA) patients with HLA-DR15. HLA-DR(-) HSPCs may evade the attack by CD4+ T-cells recognizing the autoantigen presented by HLA-DR15. The goal of this study is to clarify the immune escape mechanisms from antigen-specific T-cells by comparing the trranscriptome profile of HLA-DR(+) HSPCs and HLA-DR(-) HSPCs.
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| |
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| Overall design |
Examination of HLA-DR(+) HSPCs and HLA-DR(-) HSPCs from 3 patients
|
| |
|
| Contributor(s) |
Tsuji N, Hosokawa K, Nakao S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 09, 2021 |
| Last update date |
Jun 02, 2022 |
| Contact name |
Noriaki Tsuji |
| Organization name |
Kanazawa University
|
| Department |
Hematology
|
| Street address |
13-1 Takaramachi
|
| City |
Kanazawa |
| ZIP/Postal code |
920-8640 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA761999 |
| SRA |
SRP336354 |
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