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| Status |
Public on Oct 07, 2021 |
| Title |
Rapid evolutionary dynamics of an expanding family of Drosophila meiotic drive factors and their hpRNA suppressors |
| Organisms |
Drosophila mauritiana; Drosophila sechellia; Drosophila simulans |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
The Dox meiotic drive system distorts the sex-ratio in Drosophila simulans. Here, the authors reconstruct the step-wise emergence, and recent amplification of Dox superfamily genes in parallel with the emergence of autosomal hairpin RNA-class siRNA loci that target subsets of these putative drivers
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| Overall design |
The study reports small RNA and RNA-seq data from testis from 3 closely related species in the Drosophila simulans clade.
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| Contributor(s) |
Vedanayagam J, Lin C, Lai EC |
| Citation(s) |
34862477 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| K99 GM137077 |
Selfish meiotic drive and the role of RNAi in defending intragenomic conflict |
Sloan Kettering Institute for Cancer Research |
Jeffrey Vedanayagam |
| R01 GM083300 |
Selective regulatory and biogenesis mechanisms for microRNAs |
Sloan Kettering Institute for Cancer Research |
Eric C Lai |
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| |
| Submission date |
Oct 05, 2021 |
| Last update date |
Feb 12, 2023 |
| Contact name |
Jeffrey Vedanayagam |
| E-mail(s) |
vedanayj@mskcc.org
|
| Organization name |
Sloan-Kettering Institute
|
| Department |
Department of Developmental Biology
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| Lab |
Eric Lai
|
| Street address |
1275 York Avenue
|
| City |
New Yor |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
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| Platforms (3) |
| GPL22292 |
Illumina HiSeq 2500 (Drosophila sechellia) |
| GPL22293 |
Illumina HiSeq 2500 (Drosophila simulans) |
| GPL25637 |
Illumina HiSeq 2500 (Drosophila mauritiana) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA768815 |
| SRA |
SRP340148 |
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