|
| Status |
Public on Sep 26, 2022 |
| Title |
The amniotic fluid proteome improves prediction of imminent delivery relative to quantitative cervical length: a cross-sectional study in women with a short cervix |
| Organism |
Homo sapiens |
| Experiment type |
Protein profiling by protein array
|
| Summary |
For women identified as at risk for preterm birth attributable to a sonographic short cervix, the determination of imminent delivery is crucial for patient management. The current study aimed to identify amniotic fluid proteins that could predict imminent delivery in asymptomatic patients with a short cervix.
An aptamer-based multiplex platform was used to profile 1,310 AF proteins, and the significance of protein dysregulation was determined by moderated t-tests between women who destined to deliver within two weeks of amnicentesis.
The area under the receiver operating characteristic curve was calculated to determine whether protein abundance in combination with cervical length improved the prediction of imminent delivery after amnicentesis as compared to cervical length alone.
|
| |
|
| Overall design |
A cross-sectional study involving women who were diagnosed with a sonographic short cervix between 16 and 32 weeks of gestation and had a transabdominal amniocentesis performed within two days of the cervical length assessment.
|
| |
|
| Contributor(s) |
Gudicha DW, Romero R, Gomez-Lopez N, Galaz J, Bhatti G, Done B, Jung E, Gallo D, Bosco M, Suksai M, Diaz Primera R, Chaemsaithong P, Gotsch F, Berry SM, Chaiworapongsa T, Tarca AL |
| Citation(s) |
35821507 |
| Submission date |
Oct 19, 2021 |
| Last update date |
Sep 26, 2022 |
| Contact name |
Adi Tarca |
| E-mail(s) |
atarca@med.wayne.edu
|
| Phone |
313-577-5305
|
| Organization name |
Wayne State University
|
| Department |
Perinatology Research Branch (NIH/NICHD)
|
| Lab |
Bioinformatics and Computational Biology Unit
|
| Street address |
3990 John R.
|
| City |
Detroit |
| State/province |
Michigan |
| ZIP/Postal code |
48201 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL23119 |
SOMAscan human proteomic assay [SOMAscan Assay 1.3k] |
|
| Samples (106)
|
|
| Relations |
| BioProject |
PRJNA772718 |
Less...
More...