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Series GSE189326 Query DataSets for GSE189326
Status Public on Nov 27, 2023
Title SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ
Organism Mus musculus
Experiment type Expression profiling by array
Summary The adipose tissue is a key site regulating energy metabolism. One of the contributing factors behind this is browning of white adipose tissue (WAT), however, knowledge of the intracellular determinants of browning process remains incomplete. By generating adipocyte-specific Senp2 knockout (Senp2-aKO) mice, here we showed that SENP2 negatively regulates browning by de-conjugating SUMO from C/EBPβ. Senp2-aKO mice were resistant to diet-induced obesity and insulin resistance due to increased energy expenditure and heat production. Senp2 knockout promoted beige adipocyte accumulation in inguinal WAT by upregulation of thermogenic gene expression. In addition, SENP2 knockdown promoted thermogenic adipocyte differentiation of precursor cells isolated from inguinal and epididymal WATs. Mechanistically, sumoylated C/EBPβ, a target of SENP2, suppressed expression of HOXC10, a browning inhibitor, by recruiting a transcriptional repressor DAXX. These findings indicate that a SENP2-C/EBPβ-HOXC10 axis operates for the control of beige adipogenesis in inguinal WAT.
Overall design The transcriptomic profiles of iWAT obtained from control or Senp2-aKO mouse
Web link
Contributor(s) Lee J, Chae S, Hwang D, Chung S, Park K
Citation(s) 35196497
Submission date Nov 22, 2021
Last update date Nov 28, 2023
Contact name Sehyun Chae
Organization name Korea Brain Research Institute
Department Neurovascular Unit Research Group
Street address 61, Cheomdan-ro, Dong-gu
City Daegu
ZIP/Postal code 41062
Country South Korea
Platforms (1)
GPL13912 Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version)
Samples (8)
GSM5699227 iWAT cont_1
GSM5699228 iWAT cont_2
GSM5699229 iWAT cont_3
BioProject PRJNA782557

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE189326_Normalized_intensity_matrix.txt.gz 1.6 Mb (ftp)(http) TXT
GSE189326_RAW.tar 33.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data are available on Series record

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