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Series GSE189647 Query DataSets for GSE189647
Status Public on Dec 15, 2022
Title Astrocyte-neuron contributions to Huntington’s disease dissected with ZFPs
Organism Mus musculus
Experiment type Other
Summary We performed cell-type specific RNAseq in astrocytes and neurons in the presence or absence of ZFP transcriptional repressors in the striatum of R6/2 mouse model of HD.
 
Overall design Mutant huntingtin was reduced in a cell-specific manner either in astrocytes or neurons using zinc-finger protein (ZFP) transcriptional repressors. Cell-type specific RNA-seq using RiboTag approach was carried out in astrocytes and neurons in combination with mHTT reduction with ZFPs.
 
Contributor(s) Khakh BS, Gangwani MR
Citation(s) 36640336
Submission date Nov 26, 2021
Last update date Feb 24, 2023
Contact name Riki Kawaguchi
Organization name University of California, Los Angeles
Department Department of Psychiatry and Neurology Department of Psychiatry
Lab AMRF Functional Genomics Common Research Resource
Street address 760 Westwood Plaza, Room 37-420
City Los Angeles
State/province CA
ZIP/Postal code 90095-1759
Country USA
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (110)
GSM5705366 MG_ND_1_IP
GSM5705367 MG_ND_2_IP
GSM5705368 MG_ND_3_IP
Relations
BioProject PRJNA783944
SRA SRP348116

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE189647_metaReadCounts.txt.gz 3.4 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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