|
| Status |
Public on Mar 01, 2022 |
| Title |
Effect of TLR7/8 dual agonist 3M-052 on B cell response to melanoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
B cells potentially play a role in the immune response to melanoma, including during treatment with immune modulators. We profiled effects of 3M-052 on gene expression in draining lymph nodes of syngeneic mice bearing B16 melanoma tumors.
When B16 tumors reached 30-40 mm2 in size, they were injected intratumorally once with 3M-052 or vehicle control.
|
| |
|
| Overall design |
Draining lymph nodes from 4 mice in each group (3M-052 vs. control) were harvested 4 days after intratumoral injection of 3M-052 or control.
|
| |
|
| Contributor(s) |
Singh S, Wang Z, Davis RE, Overwijk WW, Singh M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 06, 2021 |
| Last update date |
Mar 02, 2022 |
| Contact name |
Richard Eric Davis |
| E-mail(s) |
redavis1@mdanderson.org
|
| Phone |
4437456831
|
| Organization name |
MD Anderson Cancer Center
|
| Street address |
7455 Fannin Street
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77054 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA786554 |
Less...
More...