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Series GSE19027 Query DataSets for GSE19027
Status Public on Oct 01, 2010
Title Antioxidant response gene expression in the bronchial airway epithelial cells of smokers at risk for lung cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer. This study examines the relationship between gene expression variation and genetic variation in a central molecular pathway (NRF2-mediated antioxidant response) associated with smoking exposure and lung cancer. We assessed global gene expression in histologically normal airway epithelial cells obtained at bronchoscopy from smokers who developed lung cancer (SC, n=20), smokers without lung cancer (SNC, n=24), and never smokers (NS, n=8). Functional enrichment showed that the NRF2-mediated antioxidant response pathway differed significantly among these groups.

Keywords: Global mRNA expression profiling
 
Overall design 21 total arrays (20 unique patients) run on total RNA obtained from Bronchial Epithelium of Smokers with Lung Cancer
30 total arrays (24 unique patients) run on total RNA obtained from Bronchial Epithelium of Smokers without Lung Cancer
9 total arrays (8 unique patients) run on total RNA obtained from Bronchial Epithelium of Never Smokers
 
Contributor(s) Want X, Chorley BN, Pittman GS, Kleeberger SR, Brothers JF, Liu G, Spira A, Bell DA
Citation(s) 20689807, 25179167
Submission date Nov 13, 2009
Last update date Aug 16, 2019
Contact name Avrum Spira
E-mail(s) aspira@bu.edu
Phone 617-638-4860
Fax 617-536-8093
URL http://www.pulmonomics.com
Organization name Boston University Medical Center
Department Pulmonary and Critical Care Medicine
Lab Pulmonomics Lab
Street address 715 Albany Street, R304
City Boston
State/province MA
ZIP/Postal code 02118
Country USA
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (60)
GSM15693 Sample_58_current smoker without cancer
GSM15694 Sample_71_current smoker without cancer
GSM15722 Sample_43_never smoker
Relations
BioProject PRJNA120623

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19027_RAW.tar 195.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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