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Series GSE193806 Query DataSets for GSE193806
Status Public on Jul 17, 2023
Title Early rotarod training aggravates injury and impairs functional recovery after spinal cord injury
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mice with rotarod training showed significant differences in the expression of trophic factors and cytokines, histological repair, and functional recovery when compared with the mice without training. To exlore the potential mechanism, we applied the next-generation sequence to compare the transcriptome profile between two groups. We found that there were 1299 DEGs between two groups with 586 upregulated genes and 713 downregulated genes. GO enrichment analysis revealed that DEGs, especially the downregulated genes, were primarily associated with revascularization biological process like angiogenesis, regulation of vasculature development, regulation of angiogenesis, and cellular component including postsynapse, neuron to neuron synapse, etc. On the other hand, KEGG pathway analysis showed that those significantly altered genes, also downregulated DEGs in particular, were mainly enriched in the PI3K-Akt signaling pathway.
 
Overall design Explore the gene expression profile between mice with or without rotarod training after SCI. Mice were randomly assigned to two groups: SCIT (mice with rotarod training) and SCI (mice without rotarod training).
 
Contributor(s) Junhao D, Fanqi M, Licheng Z, Peifu T
Citation https://doi.org/10.1016/j.heliyon.2023.e18158
Submission date Jan 17, 2022
Last update date Jul 17, 2023
Contact name Junhao Deng
E-mail(s) deng_junh@yeah.net
Phone 15811173069
Organization name Chinese PLA General Hospital
Street address Fuxing Road, Beijing, 100853, People’s Republic of China.
City Beijing
State/province Beijing
ZIP/Postal code 100853
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM5821742 SCIT1
GSM5821743 SCIT2
GSM5821744 SCIT3
Relations
BioProject PRJNA798021

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Supplementary file Size Download File type/resource
GSE193806_Processed_data_file.txt.gz 2.1 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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