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| Status |
Public on Jun 30, 2023 |
| Title |
RNA-seq of small cell lung cancer [PolyA RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We used CCK-8 experiment to determine the chemotherapy tolerance of small cell lung cancer cells, from which we found chemotherapy-sensitive cells (H446) and chemotherapy-tolerant cells (SHP77). By RNA-SEQ, we found 972 mRNAs with abnormal expression associated with chemotherapy tolerance, including 560 up-regulated mRNAs and 412 down-regulated mRNAs. Several miRNAs related to chemotherapy tolerance of small cell lung cancer were found through qRT-PCR verification, which helped us to further clarify the mechanism of chemotherapy tolerance of small cell lung cancer.
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| Overall design |
RNA profiles of small cell lung cancer
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| Contributor(s) |
Chao F, Li M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jan 17, 2022 |
| Last update date |
Jun 30, 2023 |
| Contact name |
fengmei chao |
| Organization name |
Anhui Provincial Cancer Hospital
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| Street address |
East Huanhu road
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| City |
Hefei |
| State/province |
Anhui |
| ZIP/Postal code |
230031 |
| Country |
China |
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| Platforms (1) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA798092 |
