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Series GSE194369 Query DataSets for GSE194369
Status Public on May 16, 2022
Title Increased intra-tumoral glucose level is associated with enhanced chemotherapeutic response in pancreatic cancer
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Pancreatic tumors are refractory to current chemotherapies, and there are no effective alternative therapies available for patients with pancreatic cancer (PC). We present an innovative approach to improve chemotherapy efficacy in preclinical models of pancreatic cancer. The effectiveness of various chemotherapies, including standard of care FOLFIRINOX, was remarkably enhanced by inducing a state of hyperglycemia. This was achieved by either providing animals with a high glucose diet or by a pharmacologic method involving streptozotocin coupled with long-acting insulin. Comprehensive integrative analyses revealed a key metabolic pathway, glutathione biosynthesis, mitigated by the high glucose diet. Combining chemotherapies with either the high glucose diet or an inhibitor of glutathione biosynthesis as a feasible approach caused a significant survival benefit in mice bearing orthotopic pancreatic tumors.
Overall design Orthotopic tumors under hyperglycemic (D30) compared to normoglycemic condition. Five independent biological replicates were used.
Contributor(s) Vaziri-Gohar A, Abbas A, Winter JM
Citation(s) 37380658
Submission date Jan 25, 2022
Last update date Sep 11, 2023
Contact name Ata Abbas
Organization name Case Western Reserve University
Department Division of Hematology & Oncology
Street address 10900 Euclid Ave
City Cleveland
State/province OH
ZIP/Postal code 44106
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (10)
GSM5834169 Normoglycemic PDX repl-1
GSM5834170 Normoglycemic PDX repl-2
GSM5834171 Normoglycemic PDX repl-3
BioProject PRJNA800377

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Supplementary file Size Download File type/resource
GSE194369_Orthotopic-tumors_normoglycemic-hyperglycemic.txt.gz 1.3 Mb (ftp)(http) TXT
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