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Series GSE196476 Query DataSets for GSE196476
Status Public on Jan 30, 2023
Title Mutant NPM1 binds chromatin and directly regulates oncogenic transcription in acute myeloid leukemia [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We use an endogenously degrader tagged NPM1c leukemia cell line that allows rapid small molecule induced degradation to show that NPM1c occupies specific chromatin targets in AML.
 
Overall design To investigate the specificity and functional relevance of NPM1 mutant binding to chromatin, we used a previously described NPM1 mutant leukemia cell line (OCI-AML3-NPM1c-FKBP12) in which only the mutant allele of NPM1 is modified to produce an endogenously tagged version of NPM1c that has an FKBP12 ta.g
 
Contributor(s) Uckelmann H, Hatton C
Citation(s) 36455613
Submission date Feb 10, 2022
Last update date Feb 01, 2023
Contact name Charlie Hatton
E-mail(s) Charles_Hatton@dfci.harvard.edu
Organization name Dana-Farber Cancer Institute
Department Pediatric Oncology
Lab Scott Armstrong/CPCT
Street address 450 Brookline Ave
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (126)
GSM5884876 293T_DF_ChIP_CRM1_steadystate_REP1_210830_CAGATC_S1
GSM5884877 293T-trns-AS1-HA_ChIP_HA_steadystate_REP1_210830_GTGAAA_S8
GSM5884878 293T-trns-MIG_ChIP_HA_steadystate_REP1_210830_AGTCAA_S3
This SubSeries is part of SuperSeries:
GSE196480 Mutant NPM1 binds chromatin and directly regulates oncogenic transcription in acute myeloid leukemia
Relations
BioProject PRJNA805173

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Supplementary file Size Download File type/resource
GSE196476_293T_MACS2_CRM1_HA_peak_interval_signal_differential_summary.xlsx 4.0 Mb (ftp)(http) XLSX
GSE196476_ChIPseq_MACS2_peak_bedtools_coverage_diffrpk_293T_CRM1_HA_Supp_S9.xlsx 2.6 Mb (ftp)(http) XLSX
GSE196476_ChIPseq_MACS2_peak_bedtools_coverage_diffrpk_OCIAML3-NPM1c-FKBP_Supp_S1.xlsx 5.9 Mb (ftp)(http) XLSX
GSE196476_ChIPseq_MACS2_peak_bedtools_coverage_diffrpk_OCIAML3_selinexor_VTP_Supp_S11.xlsx 4.4 Mb (ftp)(http) XLSX
GSE196476_OCIAML3_DMSO_sample_MACS2_peak_interval_signal_differential_summary.xlsx 59.2 Mb (ftp)(http) XLSX
GSE196476_PDX_model_MACS2_peak_interval_signal_summary.xlsx 4.7 Mb (ftp)(http) XLSX
GSE196476_RAW.tar 31.1 Gb (http)(custom) TAR (of TDF)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record
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