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GEO help: Mouse over screen elements for information. |
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Status |
Public on Sep 30, 2010 |
Title |
Murine Histone Methyltransferase Mll5, is involved in Male Gametogenesis |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Male mice but not female Mll5 -/- mice are infertile. This study showed that post-meiotic spermatogenic maturation is impaired in Mll5 -/- mice. In order to investigate the role of Mll5 in spermatogenesis, a transcriptome analysis of whole testes from Mll5 knock out and wildtype mice was performed. Affymetrix Mouse Exon chips were hybridized with testes material from three individual male mice from each wild-type or Mll5 -/- genotype, in order to identify gene regulation differences attributed to the loss of Mll5.
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Overall design |
One-way ANOVA: wildtype vs. Mll5-/-
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Contributor(s) |
Yap DB, Walker DC, McKinney S, Turashvili G, Mooslehner-Allen K, de Algara TR, Prentice LM, Fee J, d'Anglemont de Tassigny X, Colledge WH, Aparicio SA |
Citation(s) |
22069496 |
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Submission date |
Dec 24, 2009 |
Last update date |
Mar 03, 2017 |
Contact name |
Steven McKinney |
E-mail(s) |
smckinney@bccrc.ca
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Phone |
604-675-8000
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Organization name |
British Columbia Cancer Agency
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Department |
Molecular Oncology
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Lab |
Samuel Aparicio
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Street address |
675 West 10th Ave
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City |
Vancouver |
State/province |
BC |
ZIP/Postal code |
V5Z 1L3 |
Country |
Canada |
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Platforms (1) |
GPL6193 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [probe set (exon) version] |
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Samples (6)
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Relations |
BioProject |
PRJNA122541 |
Supplementary file |
Size |
Download |
File type/resource |
GSE19648_ArrayAssist_Exon_Matrix.txt.gz |
22.4 Kb |
(ftp)(http) |
TXT |
GSE19648_ArrayAssist_Gene_Matrix.txt.gz |
286.9 Kb |
(ftp)(http) |
TXT |
GSE19648_RAW.tar |
186.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
Processed data included within Sample table |
Processed data are available on Series record |
Processed data provided as supplementary file |
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