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Series GSE196558 Query DataSets for GSE196558
Status Public on Dec 31, 2022
Title Axon guidance signal ensures neurite growth pace while sensitizing repulsive cues through induction of a dual function facilitator
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: profiling the differential transcripts usage in wild type and Plxnd1 knockout condition of brain
Methods: transcriptome analysis by the RNA-seq through the mRNA pull-down
Results: We performed RNA-seq analysis from neonatal mouse striatum and found that the repulsive Semaphorin 3E (Sema3E)-Plexin-D1 guidance signaling transcriptionally upregulates Mtss1 in striatonigral projecting neurons of basal ganglia circuitry
Conclusions: our findings demonstrate a molecular mechanism in which repulsive guidance cues activate an autoregulatory program enabling growing axons to perform both avoiding repellants and continuing axonal extension in the navigation to their target
Overall design Profiling the differential transcripts usage in wild type and Plxnd1 knockout condition of brain
Contributor(s) Oh W, Kim J
Citation(s) 38526535
Submission date Feb 11, 2022
Last update date Apr 24, 2024
Contact name Jung-Woong Kim
Organization name Chung-Ang University
Department Life Science
Lab Genome Dynamics Lab
Street address 84 Heuksuk-ro Dongjak-ku
City Seoul
ZIP/Postal code 06974
Country South Korea
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (8)
GSM5889123 Brain, Plxnd1-WT, 1
GSM5889124 Brain, Plxnd1-WT, 2
GSM5889125 Brain, Plxnd1-WT, 3
BioProject PRJNA805510

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Supplementary file Size Download File type/resource
GSE196558_normalized_counts_FPKM_.txt.gz 603.8 Kb (ftp)(http) TXT
GSE196558_raw_counts.txt.gz 413.4 Kb (ftp)(http) TXT
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