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Series GSE198365 Query DataSets for GSE198365
Status Public on Sep 02, 2022
Title Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution[st41]
Organism Pleurodeles waltl
Experiment type Expression profiling by high throughput sequencing
Summary The evolution of advanced cognition in vertebrates is associated with the expansion of specialized areas in the forebrain (the six-layered neocortex in mammals and the dorsal ventricular ridge in birds and reptiles). Both areas exhibit complementary higher order brain functions, but it remains debated whether they developed convergently, or descended from a brain region already present in the last common ancestor of amniotes. To reconcile these views, we investigated the development, molecular identity, and connectivity of telencephalic neuron types in the Spanish newt, Pleurodeles waltl. These reveal that major neuron classes are conserved in tetrapods. Additionally, a glutamatergic neuron type in the ventral pallium displays key characteristics similar to the reptilian dorsal ventricular ridge (aDVR) and the mammalian piriform cortex (PC), suggesting that brain areas for advanced cognition evolved independently in mammals and reptiles and birds.
Overall design scRNAseq of Pleurodeles Waltl telencephalon
Contributor(s) Tosches MA, Woych J, Ortega Gurrola A, Deryckere A, Jaeger E, Gumnit E
Citation(s) 36048957
Submission date Mar 10, 2022
Last update date Dec 02, 2022
Contact name Maria ANTONIETTA Tosches
Organization name Columbia University
Street address 1212 Amsterdam Ave
City New York
ZIP/Postal code 10027
Country USA
Platforms (1)
GPL32009 Illumina NovaSeq 6000 (Pleurodeles waltl)
Samples (4)
GSM5945761 D1_1
GSM5945762 D1_2
GSM6251188 St41_reads
This SubSeries is part of SuperSeries:
GSE198367 Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution
BioProject PRJNA814705

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Supplementary file Size Download File type/resource 42.4 Mb (ftp)(http) RDS
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