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| Status |
Public on May 08, 2024 |
| Title |
An epigenetic gene signature underlies phenotype switching in early stage melanomas [SKMel147] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
A 122-epigenetic gene signature distinguished low- versus high-risk early stage melanomas. We sought to validate the signature, examined clinical correlates in a cohort of primary melanomas of the skin, and studied the underlying transcriptomic aberrations and changes in chromatin in cell lines representing these two groups.
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| |
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| Overall design |
mRNA profiles of SKMel147 metatastic human melanoma cell lines with siRNA scramble (n=3) and were generated by deep sequencing, in triplicate, using Illumina NextSeq500.
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| Contributor(s) |
Mendelson K, Martin T |
| Citation(s) |
38319712 |
| |
| Submission date |
Mar 11, 2022 |
| Last update date |
May 09, 2024 |
| Contact name |
Tiphaine Christiane Martin |
| E-mail(s) |
tiphaine.martin@mssm.edu
|
| Phone |
2128248403
|
| Organization name |
Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute
|
| Department |
Oncological Sciences
|
| Lab |
Parsons
|
| Street address |
1470 Madison Ave
|
| City |
New York |
| State/province |
75459 |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE198432 |
An epigenetic gene signature underlies phenotype switching in early stage melanomas. |
|
| Relations |
| BioProject |
PRJNA815291 |
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