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Series GSE198508 Query DataSets for GSE198508
Status Public on Jun 07, 2022
Title Genomic profiles of oxidative stress-induced renal cell carcinomas developed in wild-type and BRCA1+/- SD rats
Organism Rattus norvegicus
Experiment type Genome variation profiling by array
Summary Fenton reaction-based repeated oxidative stress via ferric nitrilotriacetate (Fe-NTA) causes renal cell carcinoma (RCC) with genetic alterations similar to those in humans. We conducted high-resolution microarray comparative genomic hybridization with Fe-NTA induced RCC obtained from both wild-type and BRCA1+/- rats to evaluate the involvement of BRCA1 haploinsufficiency in carcinogenesis.
Overall design The carcinogenesis protocol was started with 20 wildtype and 19 BRCA1+/- male Jcl: SD rats. 17 of each genptype of rats developed a renal cell carcinoma in total. Genomes of 8 samples from RCCs for each genotype (16 in total) were profiled on Agilent 180K rat genome CGH microarrays.
Contributor(s) Kong Y, Akatsuka S, Toyokuni S
Citation(s) 35667247
Submission date Mar 12, 2022
Last update date Jun 09, 2022
Contact name Shinya Toyokuni
Organization name Nagoya University
Department Pathology
Street address 65 Tsuruma-Cho, Showa-Ku
City Nagoya
State/province Aichi
ZIP/Postal code 466-8550
Country Japan
Platforms (1)
GPL10451 Agilent-027064 SurePrint G3 Rat CGH Microarray 4x180K
Samples (16)
GSM5949694 Renal cell carcinoma_C8W712
GSM5949695 Renal cell carcinoma_C10W2
GSM5949696 Renal cell carcinoma_C8K44
BioProject PRJNA815655

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE198508_RAW.tar 800.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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