|
| Status |
Public on Mar 23, 2023 |
| Title |
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [NimbleGen] |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
We identify an unexpected functional role for E3 in fetal reproductive system and brain. We further identify a novel mechanism of estrogen action, through recruitment of epigenetic modifiers to estrogen receptors and their target genes, which doesn’t correlated with the traditional view of estrogen potency.
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| |
|
| Overall design |
We administered E3 to pregnant mice, exposing the fetus to E3 and identified an unexpected functional role for E3 and a novel mechanism of estrogen action.
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| |
|
| Contributor(s) |
Zhou Y, Taylor HS |
| Citation(s) |
35491423 |
| |
| Submission date |
Mar 23, 2022 |
| Last update date |
Jun 23, 2023 |
| Contact name |
Yuping Zhou |
| E-mail(s) |
joezhouyp@gmail.com
|
| Organization name |
Yale
|
| Department |
OB/GYN
|
| Lab |
Taylor Lab
|
| Street address |
310 cedar street
|
| City |
new haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18163 |
NimbleGen Mouse DNA Methylation 3x720K CpG Island Plus RefSeq Promoter Array [090618_MM9_CpG_Refseq_Prom_MeDIP] |
|
| Samples (4)
|
| GSM5966779 |
Estradiol and Estriol treatment [E3-E2] |
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| This SubSeries is part of SuperSeries: |
| GSE199214 |
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract |
|
| Relations |
| BioProject |
PRJNA818917 |
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