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Series GSE199325 Query DataSets for GSE199325
Status Public on Sep 20, 2022
Title Gene network downstream plant stress response modulated by peroxisomal H2O2
Organism Arabidopsis thaliana
Experiment type Expression profiling by array
Summary Study of the effect of cadmium on KO and overexpressor mutants of glycolate oxidase-GOX2, which is one of the main sources of H202 from peroxisomes.
Reactive oxygen species (ROS) act as secondary messengers that can be sensed by specific redox sensitive proteins responsible for the activation of signal transduction culminating in altered gene expression. ROS, which are involved in different activities, elicit a wide range of protein modifications, which might elicit different gene expressions. The subcellular site, in which modifications in ROS/oxidation state occur, can also act as a specific cellular redox network signal. The chemical identity of ROS and their subcellular origin actually is a specific imprint on the transcriptome response. In recent years, a number of transcriptomic studies related to altered ROS metabolism in plant peroxisomes have been carried out. In this study, we made a meta-analysis of these transcriptomic findings to identify common transcriptional footprints for plant peroxisomal-dependent signaling at early and later time points. These footprints highlight the regulation of various metabolic pathways and gene families, which are also found in plant responses to several abiotic stresses. Major peroxisomal-dependent genes are associated with protein and endoplasmic reticulum (ER) protection at later stages of stress while, at earlier stages, these genes are related to hormone biosynthesis and signaling regulation. Further, in silico analyses allowed us to assign human orthologs to some of the peroxisomal-dependent genes, which are mainly associated with different cancer types pathologies. Peroxisomal footprints provide a valuable resource for assessing and supporting key peroxisomal functions in cellular metabolism under control and stress conditions across species.
Overall design Three independent biological replicates, each composed of leaves pooled from at least five different plants, were used per experimental condition
Contributor(s) Terrón-Camero LC, Peláez-Vico MA, Rodríguez-González A, del Val C, Sandalio LM, Romero-Puertas MC
Citation(s) 36082297
Submission date Mar 24, 2022
Last update date Sep 21, 2022
Contact name Laura Carmen Terron Camero
Phone 658638526
Organization name IPBLN
Department Bioinformática
Street address Avda. del Conocimiento 17. P. T. Ciencias de la Salud
City Granada
State/province Granada
ZIP/Postal code 18016
Country Spain
Platforms (1)
GPL13970 NimbleGen Arabidopsis thaliana Gene Expression 12x135K Array [100718_Athal_TAIR9_exp; SEQ_ID]
Samples (27)
GSM5970410 wt1
GSM5970411 wt2
GSM5970412 wt3
BioProject PRJNA819396

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE199325_RAW.tar 80.8 Mb (http)(custom) TAR (of CALLS, PAIR)
Processed data included within Sample table
Processed data provided as supplementary file

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